Associations between bacterial infections and blood pressure in pregnancy

作者：Petry Clive J^*; Ong Ken K; Hughes Ieuan A; Acerini Carlo L; Dunger David B

来源：Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health, 2017, 10: 202-206.

DOI：10.1016/j.preghy.2017.09.004

• Gestational hypertension
• Pre-eclampsia
• Antibiotics
• Pregnancy

Objectives: To test the hypothesis that bacterial infections in pregnancy are related to maternal blood pressure. Study design: Bacterial infection was assessed using antibiotic usage as a surrogate and its association with blood pressure in pregnancy tested in the Cambridge Baby Growth Study.
Main outcome measures: Antibiotic usage in pregnancy was self-reported in questionnaires. Blood pressure measurements at four time points in pregnancy were collected from the hospital notes of 622 women.
Results: Using all the available blood pressure readings (adjusted for weeks gestation) antibiotic usage was associated with a higher mean arterial blood pressure across pregnancy: antibiotics used 85 (84, 87) mmHg vs. no antibiotics used 83 (83, 84) mmHg (beta= 2.3 (0.6, 4.0) mmHg, p = 9.6x 10(-3), from 621 individuals). Further analysis revealed that antibiotic usage was associated with diastolic (beta = 2.3 (0.6, 4.0) mmHg; p = 7.0x 10-3) more than systolic blood pressure (beta = 1.4 (-0.9, 3.7) mmHg; p = 0.2). The effect size associated with antibiotic usage appeared to rise slightly after the first trimester.
Conclusions: Bacterial infection in pregnancy, as assessed by self-reported antibiotic usage, is associated with small rises in blood pressure.

• 出版日期2017-10