Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest

作者：Harinantenaina Liva; Bowman Jessica D; Brodie Peggy J; Slebodnick Carla; Callmander Martin W; Rakotobe Etienne; Randrianaivo Richard; Rasamison Vincent E; Gorka Alexander; Roepe Paul D; Cassera Maria B; Kingston David G I^*

来源：Journal of Natural Products, 2013, 76(3): 388-393.

DOI：10.1021/np300750q

Bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of Mallotus oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B (1) and C (2), together with the known mallotophenone (3). The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, mass spectrometry, and an X-ray crystal structure. Compounds 1 and 2 showed potent antimalarial activity against chloroquine-resistant Plasmodium falciparum, with IC50 values of 0.75 +/- 0.30 and 0.14 +/- 0.04 mu M, while 3 was inactive in this assay. Compounds 1-3 also displayed strong antiproliferative activity against the A2780 human ovarian cancer cell line (IC50 1.10 +/- 0.05, 1.3 +/- 0.1 and 6.3 +/- 0.4 mu M, respectively).

• 出版日期2013-3