A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

作者:Fletcher M H; Burns Lynch C E; Knouse K W; Abraham L T; DeBrosse C W; Wuest W M*
来源:RSC Advances, 2017, 7(47): 29835-29838.
DOI:10.1039/c7ra06045a

摘要

Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.

  • 出版日期2017