Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

作者：Mukhtar Mat Ropi^*; Osman Norfaizah; Awang Khalijah; Hazni Hazrina; Qureshi Ahmad Kaleem; Hadi A Hamid A; Zaima Kazuma; Morita Hiroshi; Litaudon Marc

来源：Molecules, 2012, 17(1): 267-274.

DOI：10.3390/molecules17010267

• Ochreinauclea maingayii
• neonaucline
• nauledine
• cadamine
• Rubiaceae
• alkaloid

A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, C-13-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 x 10(-5) M.

• 出版日期2012-1