Non-infectious Pulmonary Diseases and HIV

作者：Triplette M; Crothers K; Attia E F

来源：Current HIV/AIDS Reports, 2016, 13(3): 140-148.

DOI：10.1007/s11904-016-0313-0

• Complications
• Pulmonary complications
• Antiretroviral therapy
• ART
• Pulmonary disease
• Genetic predisposition
• Chronic obstructive pulmonary disease
• Review

Pulmonary complications remain among the most frequent causes of morbidity and mortality for individuals with HIV despite the advent of antiretroviral therapy (ART) and improvement in its efficacy and availability. The prevalence of non-infectious pulmonary diseases is rising in this population, reflecting both an increase in smoking and the independent risk associated with HIV. The unique mechanisms of pulmonary disease in these patients remain poorly understood, and direct effects of HIV, genetic predisposition, inflammatory pathways, and co-infections have all been implicated. Lung cancer, chronic obstructive pulmonary disease (COPD), and pulmonary hypertension are the most prevalent non-infectious pulmonary diseases in persons with HIV, and the risk of each of these diseases is higher among HIV-infected (HIV+) persons than in the general population. This review discusses the latest advances in the literature on these important complications of HIV infection.

• 出版日期2016-6