Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer

作者：Mei, ChengHan; Zhou, ShunChang; Zhu, Lin; Ming, JiaXiong; Zeng, FanDian; Xu, Rong^*

来源：Marine Drugs, 2017, 15(2): 39.

DOI：10.3390/md15020039

• fucoxanthin
• non-small-cell lung cancer
• cell cycle arrest
• apoptosis

Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumulating evidence suggests anti-proliferative effects of FX on many cancer cell lines including NSCLCs, but the detailed mechanisms remain unclear. In the present investigation, we confirmed molecular mechanisms and in vivo anti-lung cancer effect of FX at the first time. Flow cytometry, real-time PCR, western blotting and immunohistochemistry revealed that FX arrested cell cycle and induced apoptosis by modulating expression of p53, p21, Fas, PUMA, Bcl-2 and caspase-3/8. These results show that FX is a potent marine drug for human non-small-cell lung cancer treatment.

• 出版日期2017-2
• 单位华中科技大学