An Expedient Procedure for the Oxidative Cleavage of Olefinic Bonds with PhI(OAc)(2), NMO, and Catalytic OsO4

作者：Nicolaou K C^*; Adsool Vikrant A; Hale Christopher R H

来源：Organic Letters, 2010, 12(7): 1552-1555.

DOI：10.1021/ol100290a

PhI(OAc)(2) In the presence of OsO4 (cat.) and 2,6-lutidine cleaves olefinic bonds to yield the corresponding carbonyl compounds, albeit, in some cases, with a-hydroxy ketones as byproduct. A more practical and clean protocol to effect oxidative cleavage of olefinic bonds involves NMO, OsO4 (cat.), 2,6-lutidine, and PhI(OAc)(2).

• 出版日期2010-4-2