A Sonogashira Cross-Coupling/5-exo-dig Cyclization/Ionic Hydrogenation Sequence: Synthesis of 4-Substituted 3-Azabicyclo[3.1.0]hexan-2-ones from 2-Iodocyclopropanecarboxamides

作者:de Carne Carnavalet Benoit; Meyer Christophe*; Cossy Janine; Folleas Benoit; Brayer Jean Louis; Demoute Jean Pierre
来源:Journal of Organic Chemistry, 2013, 78(11): 5794-5799.
DOI:10.1021/jo400713u

摘要

A variety of 4-substituted 3-azabicyclo[3.1.0]hexan-2-ones have been prepared from 2-iodocyclopropane-carboxamides by a three-step sequence involving a copper-free Sonogashira coupling with terminal aryl- or heteroarylalkynes, followed by a 5-exo-dig cyclization and an ionic hydrogenation.

  • 出版日期2013-6-7