Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis

作者:Sun, Wen-Xia; Chen, Ying-Hua; Liu, Zhi-Zhong; Xie, Jian-Jun; Wang, Wei; Du, Ya-Ping; Chen, Yu; Shen, Xu-Liang; He, Xiao-Feng; Wu, Li-Xia; Wei, Wu; Zhang, Lin*
来源:Molecular Genetics and Genomics, 2015, 290(2): 709-725.
DOI:10.1007/s00438-014-0956-8

摘要

The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.

  • 出版日期2015-4
  • 单位南方医科大学; 长治医学院; 珠海市第二人民医院