Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma

作者：Xie, H. -Y.; Xing, C. -Y.; Wei, B. -J.; Xu, X.; Wu, J.; Chen, L. -M.; Cao, G. -Q.; Chen, H.; Chen, K. -J.; Yin, S. -Y.; Wu, L. -M.; Zhou, L.; Zheng, S. -S.^*

来源：Tissue Antigens, 2014, 84(3): 264-270.

DOI：10.1111/tan.12360

• HBV
• HCC
• IGF1R
• insulin-like signaling
• polymorphism

Although the involvement of insulin-like signaling in cancer has been well documented in various types of cancers, the association between the genetic variants in the insulin-like signaling and the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear. In this study, a total of 498 individuals including 173 HBV related cirrhosis patients, 171 HBV-related HCC patients, and 154 healthy controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in IGF1, IGF2, IGF1R and IGF2R have been genotyped by employing SNaPshot assays. We found A/A genotype at rs3743251 of IGF1R was negatively associated with HBV related HCC [odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.20-0.72, P = 0.037]; A/G genotype decreased the risk of portal vein thrombosis (OR = 0.38, 95% CI = 0.18-0.82, P = 0.01). These results indicate that rs3743251 polymorphism in IGF1R is associated with the susceptibility of HBV-related HCC.

• 出版日期2014-9
• 单位浙江大学