科研之友
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摘要
In cell-mediated immunity, specific T cell subsets proliferate in response to cytokines. But the mechanisms that limit clonal expansion to only those T cells that have recognised foreign antigen via their T cell receptor (TCR) are incompletely understood. In this issue of The EMBO Journal, Rawlings et at (2011) identify one such mechanism that acts, unexpectedly, through chromatin compaction and involves a subunit of condensin-a complex better known for restructuring chromosomes in preparation for cell division.
- 出版日期2011-1-19
