科研之友
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摘要
Vitamin E, a critical fat-soluble vitamin antioxidant, is expressed on cell membranes and prevents propagation of lipid peroxidation. alpha-Tocopherol transfer protein (alpha-TTP) is a cytosolic protein located in the hepatocytes that acts as the principal regulator of the circulating alpha-tocopherol levels. Type 2 diabetes is a metabolic disorder characterized by hyperglycemia, caused by insulin resistance. Lipid peroxidation promotes the clinical progression and development of complications in type 2 diabetes. Results of animal and human experiments on the vitamin E status in diabetes are conflicting. The present study was conducted with the objective of investigating the vitamin E status and alpha-TTP expression in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. In diabetic GK rats, increases of the alpha-tocopherol levels in the plasma and liver were observed as compared with the levels in the controls. No alternation in the CuZn-superoxide dismutase (SOD) or Mn-SOD gene expression was found in the liver of GK rats as compared with that in the controls. The GK rats showed an increase of the hepatic expression of the alpha-TTP gene as compared with the level in the controls. It can be suggested that the increased hepatic alpha-TTP gene expression levels may influence plasma alpha-tocopherol levels in the diabetic animals. Hence, investigation of the regulatory factors of alpha-TTP expression may provide important clues to highlighting the antioxidant mechanisms of vitamin E.
- 出版日期2013-2
