Association between opioid receptor mu 1 (OPRM1) gene polymorphisms and tobacco and alcohol consumption in a Spanish population

作者：Frances Francesc^*; Portoles Olga; Castello Ana; Antonio Costa Jose; Verdu Fernando

来源：Bosnian Journal of Basic Medical Sciences, 2015, 15(2): 31-36.

DOI：10.17305/bjbms.2015.243

• Tobacco
• alcohol
• drug abuse
• genetic polymorphism

Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu J. on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerstrom tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu (OPRM1) gene, using a TaqMan protocol. In males, the rs1o485o57 polymorphism was associated with total pure ethanol intake and with the risk of being an alcohol consumer. Also, this polymorphism was significantly associated with higher Fagerstrom scores. Rs1799971 had a different influence on adaptive and maladaptive patterns of alcohol use. Despite the limited sample size, our study might enrich current knowledge on patterns of alcohol use, because it encompasses both extreme and adaptive phenotypes, providing thus a wider perspective on this subject.

• 出版日期2015-5