Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study)

作者：Kofler Bettina M; Miles Elizabeth A; Curtis Peter; Armah Christopher K; Tricon Sabine; Grew Jilly; Napper Frances L; Farrell Leslie; Lietz Georg; Packard Christopher J; Caslake Muriel J; Mathers John C; Williams Christine M; Calder Philip C; Minihane Anne Marie^*

来源：Atherosclerosis, 2012, 221(2): 467-470.

DOI：10.1016/j.atherosclerosis.2012.01.042

• Apolipoprotein E genotype
• Cardiovascular
• Lipids
• Inflammation
• CRP
• Sex
• BMI

Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype x BMI/age/sex interactions. %26lt;br%26gt;APOE genotype had a significant impact on fasting total: LDL-cholesterol (TC: LDL-C) ratio, triglycerides, % HDL3, and the Framingham 10-year CVD risk score (P %26lt; 0.05), with an overall trend towards lower and higher risk in E2- and E4-carriers, respectively, relative to the wild-type E3/E3 genotype. A greater impact of genotype on TC: HDL-C was observed in females, which explained 16% of the variability in this outcome versus 6% in males. APOE genotype was also associated with plasma C-reactive protein and adhesion molecule concentrations (P %26lt; 0.05), with significant genotype x BMI interactions observed. %26lt;br%26gt;Our observations indicate that the association between the APOE genotype and CHD risk is unlikely to be homogenous and highlights the risk of inaccurate estimations of genotype-phenotype associations in population subgroups without appropriate stratification for sex and adiposity.

• 出版日期2012-4