Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of Fc gamma RIIB-deficient Mice

作者：Watanabe Makiko; Ueno Hiroshi; Suemitsu Shunsuke; Yokobayashi Eriko; Matsumoto Yosuke; Usui Shinichi; Sujiura Hiroko; Okamoto Motoi^*

来源：Acta Medica Okayama, 2012, 66(2): 143-154.

• parvalbumin
• fast-spiking interneurons
• Fc gamma RIIB
• barrel cortex
• sensory deprivation

Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of Fc gamma RIIB protein in parvalbumin-containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in Fc gamma RIIB-deficient mice (Fc gamma RIIB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between Fc gamma RIIB-/- and wild-type mice. Sensory deprivation from immediately after birth (PO) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from PO or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in Fc gamma RIIB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that Fc gamma RIIB contributes to sensory experience-regulated expression of PV.

• 出版日期2012-4