Hemodynamic evidence linking cognitive deficits in clinically isolated syndrome to regional brain inflammation

作者：Papadaki E Z^*; Simos P G; Panou T; Mastorodemos V C; Maris T G; Karantanas A H; Plaitakis A

来源：European Journal of Neurology, 2014, 21(3): 499-505.

DOI：10.1111/ene.12338

• hemodynamics
• memory
• multiple sclerosis
• neuropsychological assessment
• perfusion MRI

Background and purposeTo investigate the relation between hemodynamic measurements and memory function in patients with clinically isolated syndrome (CIS). %26lt;br%26gt;MethodsForty CIS patients were administered tests of verbal short-term/working memory and passage learning. Using dynamic susceptibility contrast MRI cerebral blood volume (CBV), cerebral blood flow and mean transit time values were estimated in 20 cerebral regions of interest, placed in normal appearing white matter (NAWM) and normal appearing deep gray matter structures, bilaterally. %26lt;br%26gt;ResultsCIS patients showed significantly impaired scores on working memory and secondary verbal memory that correlated inversely with elevated CBV values in the left frontal and periventricular NAWM, thalamus, right caudate and corpus callosum. %26lt;br%26gt;ConclusionsVerbal memory in CIS correlates inversely with elevated CBV values of brain structures involved in memory. As these hemodynamic changes, detected in CIS, are indicative of inflammation, the observed cognitive disturbances may relate to widespread brain inflammatory processes that prevail in early multiple sclerosis.

• 出版日期2014-3