Aminobisphosphonate Polymers via RAFT and a Multicomponent Kabachnik-Fields Reaction

作者：Bachler Patricia R; Schulz Michael D; Sparks Chelsea A; Wagener Kenneth B^*; Sumerlin Brent S

来源：Macromolecular Rapid Communications, 2015, 36(9): 828-833.

DOI：10.1002/marc.201500060

• aminobisphosphonate
• Kabachnik-Fields
• Moedritzer-Irani
• multicomponent reactions
• postpolymerization reactions
• reversible addition-fragmentation chain transfer

Polyacrylamides containing pendant aminobisphosphonate groups are synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and a multicomponent postpolymerization functionalization reaction. A Moedritzer-Irani reaction installs the phosphonic acid groups on well-defined, RAFT-generated polymers bearing a pendant amine. An alternate route to the same materials is developed utilizing a three-component Kabachnik-Fields reaction and subsequent dealkylation. Kinetics of the RAFT polymerization of the polymer precursor are studied. Successful functionalization is demonstrated by NMR and FTIR spectroscopy and elemental analysis of the final polymers.

• 出版日期2015-5