Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency

作者：Olusanya Bolajoko O^*; Emokpae Abieyuwa A; Zamora Tara G; Slusher Tina M

来源：Acta Paediatrica, 2014, 103(11): 1102-1109.

DOI：10.1111/apa.12735

• Acute bilirubin encephalopathy
• Child disability
• Developing countries
• Kernicterus
• Phototherapy

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders.
ConclusionLow- and middle-income countries need to pay urgent attention to G6PD deficiency to curtail the preventable burden of jaundice-related morbidity, mortality and disability.

• 出版日期2014-11