Phytochemicals from the stem wood of Sorbus lanata (D. Don.) Schauer

作者：Uddin Ghias^*; Latif Abdul; Arfan Mohammad; Ali Mumtaz; Hussain Syed Hamid; Simpson Thomas J; Cox Russel J; Choudhary Muhammad Iqbal

来源：Phytochemistry Letters, 2013, 6(1): 84-89.

DOI：10.1016/j.phytol.2012.10.002

• Sorbus lanata
• HPLC separations
• Phenolic compounds
• DPPH radical scavenging activity

Three new phenolic compounds, sorlanin (4-(3-(hydroxymethyl)-5-methoxy-7-phenyl-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-2-methoxyphenol, 1), sorbanin (2-((3,5-dimethoxy-[1,1%26apos;-biphenyl]-4-yl)oxy)-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, 2) and sorbalanin (4-(3-(hydroxymethyl)5,6-dimethoxy-2,3-dihydrobenzo[b][1,4]dioxino[2,3-g]benzofuran-2-yl)-2-methoxyphenol, 3), together with eight known compounds, polystachyol (4), isolariciresinol (5), dihydrodehydrodiconiferyl alcohol (6), tuberculatin (7), ovafolinin E (8), aucuparin (9), 2%26apos;-methoxyaucuparin (10), and tetracosyl-3-(3,4-dihydroxyphenyl)acrylate (11), were isolated from Sorbus lanata. The structures of these phytoconstituents were elucidated through extensive spectroscopic techniques, including UV, IR, 1D and 2D NMR, ESI-MS and HRESI-MS experiments. All the compounds except 9 and 10 were isolated for the first time from the genus Sorbus. The isolated compounds were also tested in DPPH radical scavenging reaction where compounds 6, 7, 10 and 11 showed significant activities with IC50 values of 9.2, 11.7, 23.0 and 33.7 mu M, respectively.

• 出版日期2013-2