A response strategy predicts acquisition of schedule-induced polydipsia in rats

作者：Gregory James Gardner; Hawken Emily R^*; Banasikowski Tomek J; Dumont Eric C; Beninger Richard J

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2015, 61: 37-43.

DOI：10.1016/j.pnpbp.2015.03.012

• Amphetamine
• Compulsivity
• Immediate early gene
• Impulsivity
• Learning
• Memory

Schedule-induced polydipsia (SIP) is excessive, non-regulatory drinking. We aimed to identify phenotypic learning traits representative of neural circuitry that underlies SIP and hypothesized that rats that are response-learners will be more susceptible in developing compulsive water drinking. Using the Y-maze, the rats were characterized as either place-or response-learners. They were exposed to the SIP protocol for a period of 21 days. Subsequent histological staining for FosB/Delta FosB examined neuronal activation associated with SIP in several brain regions. The rats with a preference for a response-learning strategy were more likely to develop SIP than the rats using a place-learning strategy. Furthermore amphetamine sensitization, observed to increase SIP, also shifted learning strategy to a response-learning strategy. No differences were observed in FosB/Delta FosB expression between SIP and non-SIP rats in the dorsolateral striatum (DLS) and CA1 region of the hippocampus. However, SIP rats had greater FosB/Delta FosB expression in prefrontal cortex regions. The rats that develop SIP have a preference for response-learning strategies and increased neuronal activation in frontal cortical regions associated with habit formation and compulsion.

• 出版日期2015-8-3