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Introduction: Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies. Clinically it can present as oligo-/amenorrhoea, hyperandrogenism and/or fertility problems. %26lt;br%26gt;Material and methods: The study involved 60 women admitted to the Department of Internal Medicine and Endocrinology at the Medical University of Warsaw. The initial evaluation, including case history and two-dimensional vaginal ultrasound, was performed by gynaecologists. All hormonal investigations (IT, free testosterone; bioT; bioavailable testosterone; T, total testosterone; T EQ, free testosterone by equilibrium dialysis; A, androstenedione; A EQ, free androstenedione by equilibrium dialysis; salA, salivary androstenedione; salT, salivary testosterone) were performed. Anthropometrical data, excess facial and body hair, acne, and menstrual cycle frequency were also assessed. %26lt;br%26gt;Results: Increased levels of T, IT, T EQ and A were noted in 20.0%, 89.8%, 100% and 28.3% of women, respectively. A very high correlation was found between salivary androstenedione and free androstenedione estimated by EQ in plasma (p %26lt; 0.05, r = 0.67), and total androstenedione in plasma (p %26lt; 0.05, r = 0.71). Correlation between salT and T was r = 0.31, p %26lt; 0.05 and salT and T EQ was r = 0.26, p = 0.04. Correlation between salA/salT and T, A in plasma (respective values r = 0.39 and r = 0.28, p %26lt; 0.01) and between salA/salT and A EQ, T EQ (respectively r = 0.34 and r = 0.48, p %26lt; 0.01) was evident. %26lt;br%26gt;Conclusions: SalA/salT ratio may be a good indicator of hyperandrogenism in women. We also confirm that measurement of androstenedione in plasma may be useful in making a diagnosis of PCOS. (Pol J Endocrinol 2012; 63 (3): 183-190)
- 出版日期2012-6
