Adipocyte fatty acid binding protein in OVA-induced asthmatic mice

作者：An, Shuhua^*; Zheng, Bojuan; Li, Jinying; Li, Quanheng; Zhang, Lianshan; Sun, Junfeng

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(7): 7365-7369.

• Asthma
• A-FABP
• mice

Objective: To investigate the expression of adipocyte fatty acid binding protein (A-FABP) in OVA-induced asthmatic mice. Methods: Healthy female BALB/c mice were randomly divided into control group and asthma group. A-FABP in lung tissues was located using immunohistochemical staining and quantified by Western blot. A-FABP in serum was quantified by ELISA. Results: A-FABP mainly expressed in the cytoplasm of airway epithelial cells (AECs), macrophages and vessel endothelial cells (VECs). The expression of A-FABP was significantly higher in asthma group than control group (P<0.05). Conclusion: A-FABP might be involved in the pathophysiological process of asthma.

• 出版日期2016
• 单位河北医科大学; 河北省儿童医院