Hydroxyapatite/poly(L-lactic acid)-chitosan Porous Scaffolds Prepared by Phase Separation Method

作者：Xu, Guojie; He, Zhihang; Huang, Qiongyu; Xiao, Xiufeng^*

来源：Polymer - Plastics Technology and Engineering, 2015, 54(12): 1223-1230.

DOI：10.1080/03602559.2014.1003232

• Bioactivity
• Chitosan
• Hydroxyapatite
• Phase separation
• Poly(L-lactic acid)

Hydroxyapatite/poly(L-lactic acid)-chitosan and poly(L-lactic acid)/chitosan porous scaffolds were prepared by phase separation technique using heated acetic acid-water as a common solvent of poly(L-lactic acid) and chitosan. The results show that the distribution of hydroxyapatite in the scaffolds is good. The porosity of the hydroxyapatite/poly(L-lactic acid)-chitosan scaffolds is nearly 85%. The hydroxyapatite particles in the scaffolds are beneficial for improving the compression property of the scaffolds. The in vitro bioactivity test shows that there is a low crystallinity of carbonate hydroxyapatite coating formed on the surface of the scaffold after immersing in simulated body fluid for 14 days, indicating that the hydroxyapatite/poly(L-lactic acid)-chitosan scaffolds have a good bioactivity.

• 出版日期2015-8-26
• 单位福建师范大学