Driving IL-17(+) gamma delta T-cell migration in allergic reactions: A new %26quot;inflammatory%26quot; role for the %26quot;homeostatic%26quot; chemokine CCL25

作者：Silva Santos Bruno^*

来源：European Journal of Immunology, 2012, 42(5): 1097-1101.

DOI：10.1002/eji.201242545

• Allergy
• Chemokines
• IL-17
• Inflammation
• d T cells

Chemokines are traditionally classified as homeostatic or inflammatory depending on whether they direct leukocyte migration in the absence or presence of inflammatory stimuli. CC chemokine ligand (CCL)25, a ligand for CC chemokine receptor (CCR)9, has mostly been characterized as a homeostatic chemokine that determines the migration pathway of T-cell progenitors within the thymus, and the recruitment of various lymphocyte subsets to the intestinal mucosa. In this issue of the European Journal of Immunology, Costa et al. [Eur. J. Immunol. 2012. 42: 12501260] describe a new inflammatory role for CCL25/CCR9 in controlling the migration of a subset of ?d Tcells committed to IL-17 production (?d17 cells) in a model of allergic pleurisy. Interestingly, the effect of CCL25 was selective for ?d17 cells, as it did not extend to other ?d or a beta T-cell subsets, and resulted in a specific increase of IL-17 (but not IL-4 or IFN-?) levels in the allergic pleura. In this commentary, I discuss these results in the context of chemokine-mediated recruitment of ?d Tcells to inflammatory sites, and the as yet unclear and controversial role of IL-17 in allergic reactions.

• 出版日期2012-5