Abdominal aortic aneurysms - glycaemic status and mortality

作者：Hjellestad Iren Drange^*; Softeland Eirik; Nilsen Roy Miodini; Husebye Eystein Sverre; Jonung Torbjorn

来源：Journal of Diabetes and Its Complications, 2016, 30(3): 438-443.

DOI：10.1016/j.jdiacomp.2015.12.015

• Diabetes mellitus
• Abdominal aortic aneurysm
• Mortality
• Glycaemic status
• HbA(1c)
• OGTT

Aims: The prevalence of diabetes mellitus (DM) and mortality with respect to glycaemic status in patients with abdominal aortic aneurysms (AAA) was evaluated. Glycaemic status was assessed by an oral glucose tolerance test (OGTT) and by HbA(1c).
Methods: Sixty-six patients with MA admitted to the vascular surgery unit for elective surgery between October 2006 and September 2007 were included. Seven patients had previously known DM. OGTT and HbA(1c) results were available from 58 patients. The patients were categorized as having DM, prediabetes and normoglycaemia according to the WHO's and American Diabetes Association's criteria.
Results: The prevalence of newly diagnosed DM according to the OGTT and HbA(1c) results were 12% and 14% respectively. Mean follow-up time was 68 months and all-cause mortality 43%. HbA(1c) was an independent predictor for mortality in the DM category. Hazard ratio of all-cause mortality in the DM category defined by the HbA(1c) values was 635, 95% [CI 1.49-27.1]; p = 0.01.
Conclusions: DM defined by HbA(1c) >= 6.5% is an important determinant of mortality following surgical treatment for AAA. Half the patients with AAA and DM were unaware of their DM diagnosis. All patients with AAA should be tested for DM using HbA(1c). The results should be confirmed in a larger prospective study.

• 出版日期2016-4