Novel bioactive parathyroid hormone and related peptides in teleost fish

作者：Canario **M^*; Rotllant J; Fuentes J; Guerreiro PM; Teodosio HR; Power DM; Clark MS

来源：FEBS LETTERS, 2006, 580(1): 291-299.

DOI：10.1016/j.febslet.2005.12.023

• parathyroid hormone
• parathyroid hormone-related peptide
• calciotropic
• receptor
• adenylate cyclase
• phospholipase C

We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodonfluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.

• 出版日期2006-1-9