Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK

作者：Williams Roger; Alexander Graeme; Armstrong Iain; Baker Alastair; Bhala Neeraj; Camps Walsh Ginny; Cramp Matthew E; de Lusignan Simon; Day Natalie; Dhawan Anil; Dillon John; Drummond Colin; Dyson Jessica; Foster Graham; Gilmore Ian; Hudson Mark; Kelly Deirdre; Langford Andrew; McDougall Neil; Meier Petra; Moriarty Kieran; Newsome Philip; O'Grady John; Pryke Rachel; Rolfe Liz; Rice Peter; Rutter Harry; Sheron Nick; Taylor Alison; Thompson Jeremy; Thorburn Douglas

来源：Lancet, 2018, 391(10125): 1097-1107.

DOI：10.1016/S0140-6736(17)32866-0

This report contains new and follow-up metric data relating to the eight main recommendations of the Lancet Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis. For alcohol, we provide data on alcohol dependence, damage to families, and the documented increase in alcohol consumption since removal of the above-inflation alcohol duty escalator. Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost. The rising prevalence of overweight and obesity, affecting more than 60% of adults in the UK, is leading to an increasing liver disease burden. Favourable responses by industry to the UK Government's soft drinks industry levy have been seen, but the government cannot continue to ignore the number of adults being affected by diabetes, hypertension, and liver disease. New direct-acting antiviral drugs for the treatment of chronic hepatitis C virus infection have reduced mortality and the number of patients requiring liver transplantation, but more screening campaigns are needed for identification of infected people in high-risk migrant communities, prisons, and addiction centres. Provision of care continues to be worst in regions with the greatest socioeconomic deprivation, and deficiencies exist in training programmes in hepatology for specialist registrars. Firm guidance is needed for primary care on the use of liver blood tests in detection of early disease and the need for specialist referral. This report also brings together all the evidence on costs to the National Health Service and wider society, in addition to the loss of tax revenue, with alcohol misuse in England and Wales costing 21 pound billion a year (possibly up to 52 pound billion) and obesity costing 27 pound billion a year (treasury estimates are as high as 46 pound billion). Voluntary restraints by the food and drinks industry have had little effect on disease burden, and concerted regulatory and fiscal action by the UK Government is essential if the scale of the medical problem, with an estimated 63 000 preventable deaths over the next 5 years, is to be addressed.

• 出版日期2018-3-17