Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

作者：Newton Cheh Christopher^*; Larson Martin G; Vasan Ramachandran S; Levy Daniel; Bloch Kenneth D; Surti Aarti; Guiducci Candace; Kathiresan Sekar; Benjamin Emelia J; Struck Joachim; Morgenthaler Nils G; Bergmann Andreas; Blankenberg Stefan; Kee Frank; Nilsson Peter; Yin Xiaoyan; Peltonen Leena; Vartiainen Erkki; Salomaa Veikko; Hirschhorn Joel N; Melander Olle; Wang Thomas J

来源：Nature Genetics, 2009, 41(3): 348-353.

DOI：10.1038/ng.328

We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.

• 出版日期2009-3