Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer

作者：Tran Lesa A; Wilson Lon J^*

来源：Breast Cancer Research, 2011, 13(2): 303.

DOI：10.1186/bcr2830

A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely applied radiofrequency magnetic field, these nanocapsules demonstrate on-off switchable release of the internally loaded drug payload. Both in vitro and in vivo studies using MT2 mouse breast cancer cell models demonstrate that the magnetic targeting of these nanocapsules allows for deep tumor penetration and subsequent on-demand release of the drug cargo, significantly reducing tumor cell viability.

• 出版日期2011