Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma

作者：Li, Xiao-Man; Lin, Xu-Yong; Xu, Hong-Tao; Yu, Juan-Han; Wang, Liang; Fan, Chui-Feng; Liu, Yang; Wang, En-Hua^*

来源：Diagnostic Pathology, 2013, 8(1): 103.

DOI：10.1186/1746-1596-8-103

• Epithelioid hemangioendothelioma
• Mediastinum
• Osteoclast-like giant cells
• Malignant fibrous histiocytoma

Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuoles in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cells can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration.

• 出版日期2013-6-21
• 单位中国医科大学