A BINOL-terpyridine-based multi-task catalyst for a sequential oxidation and asymmetric alkylation of alcohols

作者：Chen Xi; Liu Qiang; Sun Hong Bao; Yu Xiao Qi^*; Pu Lin

来源：Tetrahedron Letters, 2010, 51(17): 2345-2347.

DOI：10.1016/j.tetlet.2010.02.142

• BINOL
• Terpyridine
• Oxidation
• Aldehyde
• Alcohol
• Alkylation
• Multi-task catalyst
• Ru
• Zn
• Ti

Treatment of a BINOL-terpyridine compound with RuCl(3) generates a Ru(II) complex (R)-6. This complex is found to be a novel multi-task catalyst capable of conducting a sequential oxidation and asymmetric alkyl addition to convert primary alcohols to chiral secondary alcohols. The terpyridine-Ru(II) site of (R)-6 catalyzes an efficient oxidation of primary alcohols to aldehydes which then undergo an enantioselective alkylation to generate chiral secondary alcohols when the BINOL site of (R)-6 is combined with ZnEt(2) and Ti(O(i)Pr)(4).

• 出版日期2010-4-28
• 单位四川大学