科研之友
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摘要
One new diarylheptanoid, namely (4E,6E)-7-(3,4-dihydroxy-5-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one (1), was isolated from the rhizomes of Zingiber officinale, along with ten known ones, tetrahydrocurcumin (2), curcumin (3), 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (4), gingerenone A (5), 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)heptan-3-one (6), (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione (7), (E)-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-hept-1-ene-3,5-dione (8), shogasulfonic acid A (9), 1,5-epoxy-3-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane (10), and (3S,5S)-3,5-diacetoxy-1,7-bis(3,4-dihydroxyphenyl)heptane (11). Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. The free radical scavenging activity of 111 was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the isolated compounds were found to be better antioxidants than the positive control ascorbic acid. These compounds were also evaluated for their cytotoxicity against HeLa and MNK-45 cells using the MTT assay. Our results suggest that compounds 3 and 58 inhibited HeLa cells, and 3, 5, 7 and 8 inhibited MNK-45 cells. It was found that compound 5 was markedly cytotoxic against HeLa and MNK-45 cell lines with IC50 values of 6.4 and 7.8 mu mol/L, respectively.
