Advances in acute asthma

作者：Rodrigo Gustavo J^*

来源：Current Opinion in Pulmonary Medicine, 2015, 21(1): 22-26.

DOI：10.1097/MCP.0000000000000123

• acute asthma
• heliox
• hyperlactatemia
• magnesium sulphate
• treatment

Purpose of review
The purpose of this study is to highlight some of the recent findings related with the management of acute exacerbations in the context of the emergency department setting.
Recent findings
beta(2)-agonist heliox-driven nebulization significantly increased by 17% [95% confidence interval (CI) 5.2-29.4] peak expiratory flow, and decreased the rate of hospital admissions (risk ratio 0.77, 95% CI 0.62-0.98), compared with oxygen-driven nebulization. Other findings indicate that there is no robust evidence to support the use of intravenous or nebulized magnesium sulphate in adults with severe acute asthma, and that levalbuterol was not superior to albuterol regarding efficacy and safety in individuals with acute asthma. Finally, hyperlactatemia developed during the first hours of acute asthma treatment has a high prevalence, is related with the use of beta(2)-agonists and had no clinical consequences.
Summary
After a comprehensive review of the best quality pieces of literature published in the last year, it is possible to conclude that the goals of acute asthma management remain almost unchanged.

• 出版日期2015-1