Asymmetric Direct Michael Addition of Acetophenone to alpha,beta-Unsaturated Aldehydes

作者:Li, Wenjun; Wu, Wenbin; Yang, Juanjuan; Liang, Xinmiao; Ye, Jinxing*
来源:Synthesis (Germany), 2011, 2011(7): 1085-1091.
DOI:10.1055/s-0030-1258459

摘要

The asymmetric direct Michael addition of alpha,beta-unsaturated aldehydes with acetophenone catalyzed by a Jorgensen-Hayashi catalyst in methanol was developed and the corresponding Michael products of delta-keto aldehydes could be afforded in up to 82% yield and 98% ee.