Are vitamin D levels affected by acute bacterial infections in children?

作者：Binfield Alex^*; Aird Carolyn; Murdoch David R; Elder Peter; Walls Tony

来源：Journal of Paediatrics and Child Health, 2014, 50(8): 643-646.

DOI：10.1111/jpc.12620

• acute phase reactant
• bacterial infection
• paediatrics
• vitamin D

AimsVitamin D deficiency is associated with infectious diseases; however, it is not known whether vitamin D levels are affected by acute infection. Our aim was to establish whether 25-hydroxyvitamin D (25OHD) levels taken during an acute bacterial infection are representative of baseline levels. %26lt;br%26gt;MethodsThirty children between 6 months and 15 years of age with proven bacterial infections presenting to a tertiary paediatric referral centre had 25OHD levels taken during their acute infection and again 1 month later provided that they had recovered from their infection, had no subsequent infections and had not been taking vitamin supplements. 25OHD levels were measured by liquid chromatography mass spectrometry. %26lt;br%26gt;ResultsMean 25OHD at enrolment was 67.5nmol/L (standard deviation (SD) 22.0), and mean 25OHD at 1 month follow up was 72.7nmol/L (SD 25.8) (paired t-test P = 0.25). C-reactive protein levels were recorded in 29/30 patients at enrolment (mean 85.1mg/L, SD 83.5) and 25/30 patients at follow-up (mean 4.0mg/L, SD 3.3) (paired t-test P = 0.002). The ethnicity of the participants was New Zealand European or European Other, 26; Samoan, 2; Maori, 1; and Chinese, 1. %26lt;br%26gt;ConclusionsIn children, 25OHD levels are not affected by acute bacterial infections; 25OHD levels taken during acute bacterial infection are representative of baseline levels. 25OHD levels collected during acute bacterial infection provide reliable information for case-control studies.

• 出版日期2014-8