A comparative study of the serological response to Japanese encephalitis vaccine in HIV-infected and uninfected Thai children

作者：Chokephaibulkit Kulkanya^*; Plipat Nottasorn; Yoksan Sutee; Phongsamart Wanatpreeya; Lappra Keswadee; Chearskul Pimpanada; Chearskul Sanay; Wittawatmongkol Orasri; Vanprapar Nirun

来源：Vaccine, 2010, 28(20): 3563-3566.

DOI：10.1016/j.vaccine.2010.02.108

• Japanese encephalitis
• HIV-exposed infants
• Vaccine
• Immunogenicity
• Safety
• Thailand

We report a prospective study of mouse brain derived inactivated Japanese encephalitis (JE) vaccine, given in 3-dose EPI program to human immune deficiency virus (HIV)-exposed Thai infants. 18 HIV-infected receiving antiretroviral therapy with median baseline CD4 of 33.1%, and 92 HIV-uninfected children were studied. All but one HIV-infected child seroconverted after the second dose. The geometric mean titers (GMTs) 3 months after the second and third doses in HIV-infected vs HIV-uninfected children were 247 vs 938 (p = 0.022), and 2273 vs 24069 (p = 0.009), respectively. Urticaria or angioedema found in 4% and 6% in HIV-infected and -uninfected children, respectively (p = 1.0). The vaccine was safe and immunogenic but antibody response in HIV-infected children was not as high as in uninfected children.

• 出版日期2010-4-30