Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility

作者：Saeki Norihisa^*; Sakamoto Hiromi; Yoshida Teruhiko

来源：International Journal of Molecular Sciences, 2014, 15(5): 7958-7973.

DOI：10.3390/ijms15057958

• gastric cancer
• mucin 1
• Helicobacter pylori
• genome-wide association study
• single nucleotide polymorphism
• cancer susceptibility gene

Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.

• 出版日期2014-5