科研之友
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摘要
TBS protection of primary alcohol naphthalen-1-ylmethanol (4a) and secondary alcohol 1-(naphthalen-1-yl)ethanol (4b) has been studied under various reaction conditions. The primary/secondary selectivity is largest in the comparatively slow Lewis base catalyzed silylation in apolar solvents and systematically lower in DMF. Lowest selectivities (and fastest reaction rates) are found for TBS triflate 1b, where only minor effects of solvent polarity or Lewis base catalysis can be observed.
- 出版日期2015-7-3
