Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population

作者：Aminkeng Folefac; Weets Ilse; Van Autreve Jan E; Koeleman Bobby P C; Quartier Erik; Van Schravendijk Chris; Gorus Frans K; Van der Auwera Bart J R^*

来源：Human Immunology, 2010, 71(12): 1233-1237.

DOI：10.1016/j.humimm.2010.09.006

• Type 1 diabetes
• Genetic association
• Interleukin 2 receptor alpha
• IL 2Ra
• CD25
• Autoimmune disease
• Correlation

Our goals were to study the proposed association of IL-2RA /CD25 with type 1 diabetes in the Belgian population over a broad age range and to explore possible correlations with disease phenotypes immune markers HLA DQ INS and PTPN22 Patients (n = 1954) healthy controls (n = 2082) and families (n = 420) were genotyped for IL-2RA/CD25 rs41295061(C>A) HLA-DQ INS-VNTR and PTPN22 IL-2RA/CD25 was associated with type 1 diabetes (chi(2) = 268 p < 0 001 for alleles and chi(2) = 29 6 p < 0 001 for genotypes) The C allele (odds ratios [OR] = 1 59) and C/C genotype (OR = 1 56) were identified as susceptibility variants whereas the A allele (OR = 0 63) A/A genotype (OR = 0 14) and A/C genotype (OR = 0 69) as protective variants IL-2RA/CD25, is associated with both early-onset and late-onset type 1 diabetes but with a larger effect size in early-onset disease There was a nonsignificant tendency toward transmission distortion (p = 0 063) Except a tendency toward younger age at onset in carriers of the C/C genotype no correlations with disease phenotype immune markers HLA-DQ INS and PTPN22 were observed Also the frequency of the susceptible genotype was higher in early-onset compared with late-onset TID patients (p = 0 015) In conclusion IL-2RA/CD25 is associated with type I diabetes i

• 出版日期2010-12