An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides

作者：Joseph Nayana^*; Rajan Rani; John Jubi; Devika N V; Chand S Sarath; Suresh E; Pihko Petri M; Radhakrishnan K V

来源：RSC Advances, 2013, 3(21): 7751-7757.

DOI：10.1039/c3ra41504j

A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes or alkylidene cyclopentenes in good to excellent yields. By taking advantage of multiple points of functionalization in the synthesized trans-3-phenyl-4-hydrazino-cyclopentene, we have synthesized the antidepressant Cypenamine (trans-2-phenylcyclopentylamine).

• 出版日期2013
• 单位海洋化工研究院有限公司