Age-dependency of sevoflurane-induced electroencephalogram dynamics in children

作者：Akeju O^*; Pavone K J; Thum J A; Firth P G; Westover M B; Puglia M; Shank E S; Brown E N; Purdon P L

来源：British Journal of Anaesthesia, 2015, 115: 66-76.

DOI：10.1093/bja/aev114

• electroencephalography
• pediatric
• sevoflurane

Background: General anaesthesia induces highly structured oscillations in the electroencephalogram (EEG) in adults, but the anaesthesia-induced EEG in paediatric patients is less understood. Neural circuits undergo structural and functional transformations during development that might be reflected in anaesthesia-induced EEG oscillations. We therefore investigated age-related changes in the EEG during sevoflurane general anaesthesia in paediatric patients.
Methods: We analysed the EEG recorded during routine care of patients between 0 and 28 yr of age (n=54), using power spectral and coherence methods. The power spectrum quantifies the energy in the EEG at each frequency, while the coherence measures the frequency-dependent correlation or synchronization between EEG signals at different scalp locations. We characterized the EEG as a function of age and within 5 age groups: <1 yr old(n=4), 1-6yrold(n=12), >6-14 yr old(n=14), >14-21 yr old(n=11), >21-28 yr old(n=13).
Results: EEG power significantly increased from infancy through similar to 6 yr, subsequently declining to a plateau at approximately 21 yr. Alpha (8-13 Hz) coherence, a prominent EEG feature associated with sevoflurane-induced unconsciousness in adults, is absent in patients <1 yr.
Conclusions: Sevoflurane-induced EEG dynamics in children vary significantly as a function of age. These age-related dynamics likely reflect ongoing development within brain circuits that are modulated by sevoflurane. These readily observed paediatric-specific EEG signatures could be used to improve brain state monitoring in children receiving general anaesthesia.

• 出版日期2015-7
• 单位河北医科大学