Animal models of head and neck squamous cell carcinoma

作者：Supsavhad Wachiraphan; Dirksen Wessel P; Martin Chelsea K; Rosol Thomas J^*

来源：Veterinary Journal, 2016, 210: 7-16.

DOI：10.1016/j.tvjl.2015.11.006

• Animal model
• Head and neck squamous cell carcinoma
• Feline oral squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the most common oral cancer worldwide. Local bone invasion into the maxilla or mandible and metastasis to regional lymph nodes often result in a poor prognosis, decreased quality of life and shortened survival time for HNSCC patients. Poor response to treatment and clinical outcomes are the major concerns in this aggressive cancer. Multiple animal models have been developed to replicate spontaneous HNSCC and investigate genetic alterations and novel therapeutic targets. This review provides an overview of HNSCC as well as the traditional animal models used in HNSCC pre-clinical research. The value and challenges of each in vivo model are discussed. Similarity between HNSCC in humans and cats and the possibility of using spontaneous feline oral squamous cell carcinoma (FOSCC) as a model for HNSCC in translational research are highlighted.

• 出版日期2016-4