A Case of Switch from C3 Glomerulonephritis to Proliferative Glomerulonephritis with Monoclonal IgG Deposits

作者：Zhang, Fan; Gao, Erzhi; Liang, Shaoshan; Yang, Nannan; Wang, Jinquan^*

来源：Annals of Clinical and Laboratory Science, 2018, 48(4): 528-533.

• C3 glomerulonephritis
• Proliferative glomerulonephritis with monoclonal IgG deposits
• Monoclonal gammopathy-associated glomerulonephritis

Monoclonal immunoglobulins have been implicated in the development of C3 glomerulonephritis (C3GN) and Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID). We report a 58-year-old female who showed a switch from C3GN to PGNMID. She presented with mild proteinuria and normal renal function for the first time. Her renal biopsy showed a severe mesangial proliferation with isolated C3 deposits, thus being diagnosed as C3GN. Two years later, her condition became serious. Repeat renal biopsy showed a membranoproliferative glomerulonephritis with deposition of the kappa light chain of IgG3 in the glomeruli. She was diagnosed with proliferative glomerulonephritis with monoclonal IgG deposits (IgG3-kappa). This case demonstrates that there are several types of monoclonal gammopathy (MGP)-associated glomerulonephritis, and they can switch among each other in some patients.

• 出版日期2018-8
• 单位南京大学