Well-Defined Succinylated Chitosan-O-poly(oligo(ethylene glycol)methacrylate) for pH-Reversible Shielding of Cationic Nanocarriers

作者：Kang Chengjun; Yu Lin; Cai Guoqiang; Wang Liqun; Jiang Hongliang^*

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2011, 49(16): 3595-3603.

DOI：10.1002/pola.24798

• chitosan
• disassembly
• micelles
• pH-sensitive
• single electron transfer-living radical polymerization (SET-LRP)

A novel type of well-defined graft copolymer, succinylated chitosan-O-poly(oligo(ethylene glycol) methacrylate) (SC-POEGMA), was developed for pH-reversible poly(ethylene glyocol) (PEG) shielding of cationic nanocarriers. Chitosan-O-POEGMA (CS-POEGMA) was first synthesized via single electron transfer-living radical polymerization of oligo(ethylene glyol) methacrylate (OEGMA) using O-brominated chitosan (CS-Br) as a macromolecular initiator and Cu(I)Br/1,1,4,7,10,10-hexamethyltriethylenetetramine as a catalyst. The subsequent succinylation of the chitosan backbone gave the titled copolymers. The content of POEGMA in CS-POEGMA could be widely modulated by varying the degree of bromination and feed ratio of OEGMA to CS-Br, without compromising the amino density of chitosan backbone. The hierarchical assembly between SC-POEGMA and trimethylated chitosan-O-poly(e-caprolactone) (TMC-PCL) micelles was further studied. At pH 7.4, the stoichiometric interactions between SC and TMC segments to form polyampholyte-polyelectrolyte complexes led to the formation of PEG-shielded micelles. The hierarchially assembled micelles could be disassembled into the pristine TMC-PCL micelles, when the medium pH was below a certain pH (pH phi). By varying the degree of succinylation of SC-POEGMA, the pH phi value could be facilely modulated from 6.5 to 3.5 to meet the needs for specific biomedical applications.

• 出版日期2011-8-15
• 单位浙江大学