Novel Trifluoromethyl Pyridine Derivatives Bearing a 1,3,4-Oxadiazole Moiety as Potential Insecticide

作者：Xu, Fangzhou; Wang, Yanyan; Luo, Dexia; Yu, Gang; Wu, Yikun; Dai, Ali; Zhao, Yonghui; Wu, Jian^*

来源：ChemistrySelect, 2018, 3(10): 2795-2799.

DOI：10.1002/slct.201800123

• Insecticidal activity
• 1
• 3
• 4-Oxadiazole
• Synthesis
• Trifluoromethyl pyridine

A series of trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety was synthesized and characterized by (HNMR)-H-1, (FNMR)-F-19, (CNMR)-C-13, and HR-MS. The bio-assay results indicated that some of the synthesized compounds exhibited good insecticidal activity against Mythimna separate and Plutella xylostella. Most of the synthesized compound showed 100% activity against the two pests at 500mgL(-1); in practically, the value of median lethal concentration (LC50) for some title compounds was much lower than that of commercial chlorpyrifos. Preliminary structure-activity relationship was also discussed.

• 出版日期2018-3-14
• 单位贵州大学