A Case Series and Review of Bisphosphonate-associated Orbital Inflammation

作者：Lefebvre Daniel R^*; Mandeville John T; Yonekawa Yoshihiro; Arroyo Jorge G; Torun Nurhan; Freitag Suzanne K

来源：Ocular Immunology and Inflammation, 2016, 24(2): 134-139.

DOI：10.3109/09273948.2014.942747

• Bisphosphonate
• idiopathic orbital inflammation
• orbital inflammation
• orbital pseudotumor
• zoledronate

Purpose: To report the largest series of new cases to date of bisphosphate-associated orbital inflammation.
Methods: A retrospective case review of patients with orbital inflammation following treatment with systemic bisphosphonate.
Results: Six patients over an 18-month period (2 males, 4 females) with an average age of 62.2 years had onset of orbital inflammatory symptoms 1-11 days after intravenous bisphosphonate infusion or, in 1 case, 4 weeks after initiation of oral bisphosphonate therapy. Imaging revealed diffuse orbital involvement in 3 cases, isolated lateral rectus muscle involvement in 2 cases, and superior rectus levator involvement in 1 case. Two patients' symptoms resolved spontaneously within 2 weeks, and 3 responded rapidly and completely to corticosteroid therapy. The 1 patient on oral bisphosphonate had a slower but complete response to corticosteroid treatment.
Conclusion: Clinicians should be aware of the association between acute orbital inflammation and recent treatment with systemic bisphosphonate medication.

• 出版日期2016-4