A method for identifying the origin of chondroitin sulfate with near infrared spectroscopy

作者：Zang Hengchang; Li Lian; Wang Fengshan^*; Yi Qiong; Dong Qin; Sun Chunxiao; Wang Jinfeng

来源：Journal of Pharmaceutical and Biomedical Analysis, 2012, 61: 224-229.

DOI：10.1016/j.jpba.2011.12.011

• Chondroitin sulfate
• Near infrared spectroscopy
• Origin identification
• SVM

The object of this study was to explore the feasibility of support vector machine (SVM) to identify the origin of chondroitin sulfate (CS) by near infrared spectroscopy. 96 batches CS from three different origins were collected in this research, 66 batches of which were chosen for training set by Kennard-Stone (KS) method and the rest were used for testing. Through the comparison of pretreatment methods of standard normal variate transformation (SNV), multiplicative scatter correction (MSC), Savitzky-Golay (SG) smoothing and derivative with SG smoothing, a SVM discrimination model was constructed, of which the prediction result is 100% accurate with the pretreatment of first derivative and SG smoothing with 15 points. The result indicated that it had great potential using SVM to identify the origin of CS.

• 出版日期2012-3-5
• 单位山东大学