A cold radial maze for long-lasting spatial memory in mice

作者：Vizi Sandor^*; Mansuy Isabelle M

来源：Journal of Neuroscience Methods, 2013, 213(2): 274-281.

DOI：10.1016/j.jneumeth.2012.12.016

• Transgenic
• Mouse
• Behavior
• Method
• Spatial learning
• Memory

Here we report the establishment of a novel spatial learning and memory test called the cold radial maze. It is specifically designed for mice, with all conditions tailored to their natural behaviors. The cold radial maze is a dry-land test with easy-to-measure variables that relies on a consistent motivation system and limits the moderately adverse experience to the duration of testing. Training on this maze produces a long-lasting, resistant, and reversible spatial memory in mice in a reproducible way, without introducing undesirable side effects typically produced in other spatial learning tests. This novel behavioral technique may prove useful in studying mouse models of memory impairment-associated human conditions.

• 出版日期2013-3-15