Novel therapeutic approaches to the treatment of metastatic breast cancer

作者：Fernandez Yolanda^*; Cueva Juan; Palomo Andres G; Ramos Manuel; de Juan Ana; Calvo Lourdes; Garcia Mata Jesus; Garcia Teijido Paula; Pelaez Ignacio; Garcia Estevez Laura

来源：Cancer Treatment Reviews, 2010, 36(1): 33-42.

DOI：10.1016/j.ctrv.2009.10.001

• Novel
• Targeted
• Metastatic breast cancer
• Cytotoxic

Metastatic breast cancer is ultimately an incurable disease, although recent data have shown that its incidence is decreasing and that patients with metastatic breast cancer live longer. This improvement in survival seems to be linked with the introduction of new therapeutic agents, novel combinations of existing therapies and targeted therapies. Our increasing understanding of the molecular biology of metastatic disease has allowed the development of therapies aimed at specific molecular targets. Some of these have already been approved for the treatment of metastatic breast cancer in combination with cytotoxics, and others have shown promising results regarding disease-free survival, overall response rates and time to disease progression. Given the enormous amount of information about drug discovery in cancer, it is important to be familiar with the present state of the treatment of metastatic breast cancer. The purpose of this review is to provide an update on the development of some of the most promising novel agents and treatment strategies in metastatic breast cancer.

• 出版日期2010-2