AHL-dependent quorum sensing inhibition: Synthesis and biological evaluation of alpha-(N-alkyl-carboxamide)-gamma-butyrolactones and alpha-(N-alkyl-sulfonamide)-gamma-butyrolactones

作者：Boukraa Mohamed; Sabbah Mohamad; Soulere Laurent^*; El Efrit Mohamed L; Queneau Yves; Doutheau Alain

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(22): 6876-6879.

DOI：10.1016/j.bmcl.2011.09.010

• Quorum sensing
• Inhibition
• AHL
• Reverse-amide
• Reverse-sulfonamides

New N-acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a reverse-amide one have been studied as AHL QS modulators. The series of compounds consists of alpha-(N-alkyl-carboxamide)- gamma-butyrolactones, alpha-(N-alkyl-sulfonamide)-gamma-butyrolactones, and 2-(N-alkyl-carboxamide)-cyclopentanones and cyclopentanols. Most active compounds exhibited antagonist activities against LuxR reaching the 30 mu M range.

• 出版日期2011-11-15